Inhibitory and bactericidal activities of Lippia origanoides essential oil against Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa multidrug resistant

The objective of this study was to evaluate the antimicrobial potential essential oil (EO) from L. origanoides against Gram-negative bacteria with multidrug resistance (MDR) phenotype and correlate results obtained genetic profile these microorganisms. extracted leaves plant by steam dragging condensation Clevenger equipment, chemical components were identified quantified gas chromatography coupled mass spectrometry flame ionization detector. Twenty clinical isolates one standard strain each species analyzed: E. coli, K. pneumoniae P. aeruginosa (n=63). antibacterial evaluated broth microdilution tests. Thymol is prevalent component (87.37%). EO at a concentration 312 μg/mL effective in inhibiting 52% coli strains about 38% pneumoniae. On other hand, for 2,500 needed obtain growth inhibition approximately strains. Among genes detected, highest prevalence blaCTX-M 1/2, however, even presence genes, an action observed. Therefore, suggest that presented efficient use fight infections MDR